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Example sentences for: alkb

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The specific action of AlkB on ssDNA suggests that ssRNA could be the substrate for other members of this family.
The sixth position after the conserved basic residue is invariably occupied by a bulky residue that is either arginine (in AlkB) or phenylalanine or tryptophan in all other members of this fold [ 8, 9, 10] (Figure 1).
The clavaminic acid synthase, an outlier of this latter family, has its own characteristic inserts, including a giant (approximately 70 amino acids) insert between strands 4 and 5 [ 8], and some members of the AlkB family have smaller inserts in the same position (Figure 1).
The predicted 2OG-Fe(II) dioxygenase activity of AlkB is probably involved in the detoxification of methylated bases in ssDNA, possibly through hydroxylation of the methyl groups, resulting in less toxic base derivatives.
For example, the insert between the fifth and sixth strand in AlkB is predicted to contain an extra strand, whereas in the small-molecule dioxygenase (IPNS/ethylene-forming enzyme (EFE)) family, the same region forms (or is predicted to form) a short helix (Figures 1, 3).