Example sentences for: akr

How can you use “akr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In the model for the pheromone response network, NetSearch inserted Akr1p, a known inhibitor of the pheromone pathway [ 15 ] , between Ste3p and the G protein complex (Ste4p/Ste18p/Gpa1p).

  • This genetic uniformity is important for the analysis of complex diseases because it allows repeated and therefore accurate assessment of phenotypes associated with the AKXD28 mix of D2 and AKR/J genomes.

  • An AKR/J modifier(s) likely suppresses IPD in AKXD28

  • Other explanations for the absence of an IPD phenotype in AKXD28 include: inheritance of an AKR/J modifier gene(s) that suppresses the IPD phenotype, a spontaneous reversion of the ipd mutation in AKXD28 mice, or the spontaneous occurrence and fixation of the ipd mutation in strain D2 after the derivation of the AKXD28 strain.

  • It includes Far1p, a protein necessary for pheromone-induced cell cycle arrest in G1 [ 11 ] , Mpt5p, a protein necessary for recovery from cell cycle arrest [ 12 ] , and Bem1p and Sph1, both of which are necessary for establishment of cell polarity during shmooing and budding [ 13 14 ] . In our protein-interaction map there is no direct interaction between a pheromone receptor (Ste2p or Ste3p) and any component of the heterotrimeric G protein complex (Ste4p/Ste18p/Gpa1p), so NetSearch drew indirect paths through Akr1p, a known inhibitor of signaling in the pheromone pathway [ 15 ] . The predicted network does not include the GTPase Cdc42p (paths were instead drawn preferentially through its cofactor Cdc24p, which physically interacts with Ste4p) or Ste20p, because of missing interactions in the protein-interaction map.

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