Words similar to akap
Example sentences for: akap
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Consistent with the observed mitochondrial staining by anti-D-AKAP1, it was shown previously that one of the two alternative NH2-terminal motifs of this AKAP is necessary and sufficient for targeting to mitochondria [ 28 ] . Interestingly, another AKAP governs voltage-dependent potentiation of L-type calcium channels through anchoring of PKA in transverse tubules [ 36 ] . Because this potentiation is not dependent on RIIα, it is thought that RIα is capable of this AKAP-directed modulation of calcium channel activity [ 37 ] .
At least one AKAP, AKAP 450 is a large coiled-coil protein attaching PKA to the centrosome [ 19 ] .
This putative association is strengthened by finding for the first time that targeting of RIα requires the AKAP binding surface [ 17 ] . Yotiao is another AKAP enriched at the NMJ, but appears to bind only RII [ 30 ] . PKA phosphorylates the nAChR when stimulated at the synapse by the neuropeptide CGRP and by adenosine from muscle responding to acetylcholine [reviewed by [ 31 ] ]. This phosphorylation may regulate the degradation of the nAChR [ 32 ] . Consistent with the action at the presynapse, it was shown that PKA facilitation of acetylcholine release is dependent on nerve endplate calcium concentration [ 33 ] . Based on our observation of colocalization with synaptophysin at presynaptic vesicles, RIα may be the isotype that influences this release of neurotransmitter.
This observation is supported by previous work that demonstrated RIα codistribution with nAChR [ 19 ] and D-AKAP1 [ 17 ] suggesting that this AKAP is the anchoring protein recruiting RIα to this membrane.
PKC may bind to this anchoring protein through displacement of the pseudosubstrate, thus inhibiting the kinase activity, by analogy with a functionally similar scaffolding AKAP, AKAP79 [ 52 ] .
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