Words similar to ais-affected

Example sentences for: ais-affected

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In contrast, SAM analysis identified 1,664 transcripts that differed significantly between proliferating and confluent cells, and 1,232 transcripts that differed between fibroblasts derived from AIS-affected individuals and normal male foreskin.
We have previously used a similar approach to delineate the transcriptional programs activated in prostate cancer cells in response to androgen [ 9 ] . We had hoped that comparison of transcriptional responses of normal fibroblasts to those from AIS-affected individuals with varying degrees of genital ambiguity would provide still further insights into androgen's role in genital morphogenesis.
These female AIS-affected individuals are thought to have acquired their AR gene mutations post-zygotically [ 12 ] . ARD364, which showed AR protein expression and binding in the range of normal male foreskin fibroblasts ( [ 7 ] and see Table 1), despite its origin from anatomically female genitalia, had a gene-expression pattern indistinguishable from foreskin fibroblasts of normal males (Figure 2).
Comparison of expression patterns in genital fibroblasts from normal and AIS-affected individuals, and fibroblasts from extragenital sites, offers possible insights into the programs that underlie genital development.
Comparison of gene-expression patterns in genital fibroblasts from normal and AIS-affected individuals, and in fibroblasts from extragenital sites, may offer clues to the programs that underlie external genital development.