Words similar to agouti-related

Example sentences for: agouti-related

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Hypothalamic proopiomelanocortin (POMC) and agouti-related peptide (AGRP) mRNA and pituitary POMC mRNA were measured by Northern blot analysis as previously described [ 6 ] . Briefly, total RNA was extracted in TRIzol (GIBCO BRL, Gaithersburg, MD) and three micrograms of total RNA from hypothalamus, estimated by spectrophotometer and verified by gel electrophoresis, was subjected to Northern blot analysis to measure POMC and AGRP mRNA.
Reduction in hypothalamic melanocortin tone, caused by reduction in proopiomelanocortin (POMC) mRNA and elevation in agouti-related peptide (AGRP) mRNA, is thought to play a key role in mediating nutritional effects on neuroendocrine function [ 1 2 ] . Thus fasting [ 3 4 ] , insulin deficiency [ 5 ] , and leptin deficiency [ 4 ] are all associated with reduced hypothalamic melanocortin tone.