Example sentences for: adp-ribosylation

How can you use “adp-ribosylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This small member of the Ras GTPase superfamily has been implicated in fibroblast models of integrin dependent actin stress fiber formation, focal contact assembly [ 13 ] , and gene induction via the serum response element [ 14 ] . Studies of Rho function have been facilitated by the use of specific toxins such as Clostridium botulinum toxin C3 which catalyses the ADP-ribosylation and inactivation of Rho [ 15 16 17 ] . The function of this GTPase and related family members such as Rac and Cdc42 has been extensively studied in the fibroblast model.

  • Although ADP-ribosylation of Rho does not significantly alter the subcellular distribution of RhoA, Rho activity is inhibited.

  • The phenotype induced by ADP-ribosylation of Rho in T lymphocytes appeared different than that induced in fibroblast models, where microinjection of C3 results in fibroblast retraction of pseudopodia, with the cell body rounding up eventually to become non-adherent [ 17 ] . Video time-lapse microscopy demonstrated the elongation of aberrant pseudopods in HPB-ALL cells plated on the β1 substrate VCAM-1, rather than an altered retraction of already formed pseudopods.

  • DGW drafted the manuscript, performed ADP-ribosylation experiments, adhesion and spreading assays, and immunofluorescence.

  • 3G) interacts with G protein-coupled receptor kinases, and exhibits ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity.


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