Example sentences for: adenovirus

How can you use “adenovirus” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 1C), the ability of these cells to be transduced by adenovirus was also determined.

  • In designing an NFATp-responsive DNA template, we positioned three high-affinity NFAT-binding sites upstream of the adenovirus E1b TATA box and the CAT gene.

  • In retrospect, there were many clues that there were problems with the adenovirus vector, clues that neither the investigator nor the institution pursued.

  • Unfortunately, naive lymphocytes are not susceptible to infection with adenoviruses due to lack of detectable expression of a viral receptor, such as the coxsackie/adenovirus receptor (CAR), which is required for efficient viral attachment [ 8 9 10 ] . The CAR protein contains two extra-cellular immunoglobulin-like (Ig) domains, the first of which appears sufficient for binding to the adenoviral fiber knob protein [ 11 12 ] . Expression of either human or murine CAR in various cell lines has been shown to facilitate gene transfer by recombinant human adenoviruses [ 8 9 10 13 ] . Stable transfection of transformed murine B and T cells lines with human CAR (hCAR) lacking its cytoplasmic domain rendered them susceptible to adenoviral transfection, establishing that lymphoid cells can be permissive hosts for adenoviral transduction and demonstrating that the cytoplasmic domain of CAR is not required for viral entry [ 13 ] . More recently, mice transgenic for full length [ 14 ] or truncated hCAR [ 15 ] have been described in which adenoviral transduction of primary lymphocytes has been demonstrated.

  • The intra tumoral injection of 10 10iu adenovirus resulted in the transduction of only 1-2% of the tumour cells, mostly limited around the needle track (Table 1).


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