Example sentences for: adenosine

How can you use “adenosine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The human FHIT gene, located at the chromosome 3 fragile site FRA3B, is inactivated early in the development of many tumors [ 1 ] . Murine Fhit is also located at a fragile site [ 2 3 ] and mice heterozygous for disruption of Fhit , given low intragastric doses of the mutagen N-nitrosomethylbenzylamine, develop stomach and sebaceous tumors [ 4 ] that can be prevented by viral Fhit expression [ 5 ] . Fhit, a dimer of 147 amino acid subunits, is a member of the histidine triad (HIT) superfamily of nucleotide hydrolases and transferases [ 6 7 ] . Members of the Hint branch of the HIT superfamily are found in all forms of life [ 8 ] . The S. cerevisiae Hint homolog, Hnt1, and rabbit Hint possess adenosine monophosphoramidase activity that functions in yeast to positively regulate function of Kin28, Ccl1 and Tfb3, which constitute the kinase component of general transcription factor TFIIH [ 9 ] . A new Hint related protein, Aprataxin, is mutated in individuals with ataxia with oculomotor apraxia [ 10 11 ] and has a yeast homolog termed Hnt3 [ 9 ] . Members of the Fhit branch of the HIT superfamily have been found in fungi [ 12 13 ] , animals [ 2 14 15 ] and plants [ 7 ] and hydrolyze diadenosine tetraphosphate, diadenosine triphosphate and other 5'-5"'-dinucleoside polyphosphates.

  • However, we agree that complete substitution of DAP for adenosine may cause specificity to decline in certain sequence contexts, which may limit its usefulness in microarray applications.

  • Full substitution of adenosine by DAP showed varied effects on specificity in the four different probe sequences.

  • Indeed, although not evident from its name, P2RX acts as a receptor for a phosphorylated form of adenosine (adenosine triphosphate).

  • The factor V Leiden mutation is located in exon 10, 11 nucleotides 5' of the start of intron 10 at nucleotide 1691, where an adenosine replaces guanidine [ 15].


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