Example sentences for: actwith

How can you use “actwith” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It also suggests that antagonists should bind Smo actwith a lower affinity than they bind Smo wt, while the agonist should bind with a higher affinity, as it prefers the active conformation.

  • The two Hh-signaling antagonists, KAAD-cyclopamine and Cur61414, have shown decreased potency on Smo act-expressing cells, leading to the speculation that they may bind this mutant form of Smo less well than the wild-type form [ 11 17 ] . We sought to determine whether the Hh agonist binds Smo actwith a higher affinity, an observation seen with certain ligands and constitutively active mutants of GPCRs [ 29 ] . To perform this experiment, we isolated membranes from cells transfected with a cDNA construct encoding a tryptophan-to-leucine mutation at residue 539 (W539L) of murine Smo.

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