Example sentences for: activate

How can you use “activate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To determine whether RSV and TNFα activate NF-κB differently, we examined the effects of NAC and DEX on Rel A and p50 binding activity.

  • For example, imatinib is effective in treatment of chronic myelomonocytic leukemia with gene rearrangements that constitutively activate PDGFRB [3], of hypereosinophilic syndrome with activating mutations in PDGFRA [4], and of gastrointestinal stromal cell tumors associated with activating mutations in KIT [5] (all reviewed in [6]).

  • These results are consistent with the recruitment model for transactivation and suggest that peptides may act as bridging molecules [ 3 ] . Such short peptidic sequences that activate transcription may be useful in the context of drug discovery.

  • BMPs activate Smad-1 by binding to type I and type II serine-threonine kinase receptors [ 40 41 ] . Specific receptor subunits shown to bind BMPs include BMP receptor type IA (BMPR-IA), BMPR-IB, BMR-II, activin receptor type I (ActR-I), and ActR-II [ 42 43 44 ] . BMP ligands can bind to either type I or type II receptor subunits independently, but both receptor types are required for high-affinity binding and signaling [ 40 ] . The finding that the soluble BMPR-IA-Fc chimera significantly inhibits BMP-5 induced dendritic growth suggests that BMP-5 may be activating the Smad-1 signaling pathway via interactions with BMPR-IA.

  • Moreover, Src family kinases have been found to phosphorylate and activate Btk, Itk, Tec and Rlk when co-expressed [ 16, 19, 21, 22, 23].


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