Example sentences for: achr

How can you use “achr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • [ 5 ] . BDNF transiently stabilizes silent NM synapses during the period of transition from polyneuronal to mononeuronal innervation of skeletal muscle fibers [ 6 ] . BDNF and CNTF cooperatively affect efficiency of embryonic xenopus neuromuscular synapses in culture [ 7 8 ] . BDNF stimulates transmitter release from neuromuscular synapses [ 9 ] and enhances the efficiency of transmission at the neuromuscular synapse [ 10 ] . BDNF, together with NT-3, can restore neuregulin levels and a normal distribution of AchR at the neuromuscular junction blocked with curare [ 11 ] . BDNF, in conjunction with fibronectin, increases spontaneous synaptic currents in the cultured embryonic xenopus neuromuscular junction [ 12 ] . BDNF down-regulates AchR clustering, most likely by binding to TrkB expressed in myocytes [ 13 ] . BDNF downregulates agrin levels in muscle but increases neuregulin in ventral horn spinal motor neurons at the time when they form neuromuscular synapses [ 14 ] .

  • Thus there appears to be a "one way correlation"; whether the stimulus is agrin or laminin AChR aggregation is an excellent predictor of α-DG aggregation, but the converse is not found (see particularly [ 4 ] ). This lack of reciprocity will of course reduce the label correlation as measured in the present study.

  • Quantitative analyses of the α-DG distributions are summarized in Figure 4(the observed AChR aggregates were consistent with the observations presented above but were not pooled with those data because they were not performed on matching sister cultures).

  • AChR Nicotinic acetylcholine receptor

  • Taken together these observations have led to the hypothesis that LN1 serves as a secondary or supporting stimulus for agrin induced AChR aggregation [ 1 2 24 ] . The present study is directed at a quantitative examination of the interaction between the signal transduction pathways for agrin and LN1 induction of AChR aggregates and colocalized α-DG aggregates.


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