Example sentences for: achbp

How can you use “achbp” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The model for lerisetron binding will be further refined as its interactions with other binding site amino acids are investigated [ 26 32 33 ] . Of particular interest would be potential interactions of the N-benzyl group that would account for the decrease in binding affinity of analog 2. Additional information gained from comparison of our model with the recent crystal structure of the AChBP demonstrates that lerisetron can be roughly 'fit' into the binding site such that all the residues line up as shown in our model.

  • Surprisingly, the ester moiety of acetylcholine does not seem to interact with the cys-loop of the receptor, as previously suggested by photoaffinity labeling [ 12 ] , but is engaged in similar type of interaction as that observed with the acidic group of HEPES in the AChBP crystal structure [ 6 ] . It is possible that the reactive di-azo group of the photosensitive agonist used in photoaffinity labeling would extend towards the cys-loop, while the conformation of the bound agonist remains in agreement with our model.

  • First, the sequences of the five nAChR monomers (alpha3, alpha4, alpha7, beta2 and beta4) were aligned to AChBP in a multi-protein sequence alignment.

  • Previous reports have shown on other systems that a single-residue mutation in a receptor is sufficient for the development of specific ligands [ 13 14 ] . Based on the recent crystal structure of AChBP, we could propose a detailed description of the structural variations of nAChR subtypes.

  • The amino acids W89, R91 Y140, Y142 and Y152 of the 5HT 3 A R can be aligned with W53, Q55, L102, R104, and M114 of the AChBP (Figure 6).


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