Example sentences for: abrogating

How can you use “abrogating” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Over the last decade, RNA interference (RNAi), mediated by short interfering double-stranded RNA molecules (siRNA or dsRNA), has been gradually recognized as a major mechanism of post-transcriptional gene silencing (PTGS) in species as diverse as plants, Drosophila, and C. elegans [ 1 ] . Recently, 21-nucleotide long dsRNA molecules corresponding to specific mRNA sequences, when introduced into mammalian cells in culture, have been shown to be highly effective in degrading the cognate mRNAs and thus abrogating the expression of the corresponding proteins [ 2 ] . Although the exact mechanism of PTGS is currently unknown and is an area of intense research, the successful use of this phenomenon in cultured mammalian cells has raised the exciting prospect that it can be used as a simple strategy for phenotypic ablation of mammalian gene function ex vivo without the time-consuming and expensive construction of transgenic animals.

  • In the Pan-Arab daily al-Hayat , Abdelwahhab Badrakkhan wrote that the United States, by abrogating to itself the right to decide on the use of military force, had effectively "delegitimized" the United Nations.

  • Strain effects are unlikely to have played a role in this lack of a neoplastic phenotype, as mice with the same background as the one we used have previously been shown to develop medulloblastomas [ 12 ] . We further attempted to induce CNS tumors by abrogating p53 function in conjunction with transgenic β-catenin expression.

  • 1(lane 'La'), the anti-lamin dsRNA, while abrogating lamin protein (data not shown) had no effect on RSV protein synthesis.

  • In particular, even a low level of viremia correlates with a low or undetectable frequency of interleukin-2-producing HIV-1-specific memory CD4+ T cells endowed with proliferative capacity in vitro [36,37,38,39], thus abrogating CD4+ T cell help crucial to maintain efficacy of CD8+ T cell functions.


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