Example sentences for: abrogate

How can you use “abrogate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Properly designed synthetic 21-nucleotide long double-stranded RNA (dsRNA) molecules can effectively and specifically abrogate translation of target RNAs without activating a general interferon response.

  • The anti-F dsRNA also had no effect on P protein levels, suggesting that such dsRNAs do not activate a general antiviral response that might abrogate all viral mRNA translation.

  • We have recently reported the role of the inhibitor of NF-κB (IκB) family member Bcl-3 in IL-1-induced MMP-1 expression [ 24 ] . Here we show that overexpression of Bcl-3 can partly abrogate CDDO's inhibitory effects on MMP-1 in SW-1353 cells, suggesting that Bcl-3 might be a target for CDDO.

  • Consistent with this, the T790M mutation has been shown not to abrogate the catalytic activity of wild-type EGFR [22].

  • This agrees with in vitro work [ 26] that showed that blockade of TGF-β signaling did not abrogate the growth inhibitory effect of tamoxifen on breast cancer cells.


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