Example sentences for: ablation

How can you use “ablation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Over the last decade, RNA interference (RNAi), mediated by short interfering double-stranded RNA molecules (siRNA or dsRNA), has been gradually recognized as a major mechanism of post-transcriptional gene silencing (PTGS) in species as diverse as plants, Drosophila, and C. elegans [ 1 ] . Recently, 21-nucleotide long dsRNA molecules corresponding to specific mRNA sequences, when introduced into mammalian cells in culture, have been shown to be highly effective in degrading the cognate mRNAs and thus abrogating the expression of the corresponding proteins [ 2 ] . Although the exact mechanism of PTGS is currently unknown and is an area of intense research, the successful use of this phenomenon in cultured mammalian cells has raised the exciting prospect that it can be used as a simple strategy for phenotypic ablation of mammalian gene function ex vivo without the time-consuming and expensive construction of transgenic animals.

  • The major findings are: (i) The ablation is highly efficient: nanomolar concentrations of dsRNA can lead to a 10-20 fold reduction of the corresponding protein.

  • Fasano et al [ 3 ] reported that the ideal masking agent should have the same ablation rate to that of the cornea, be biocompatible and adhere well to the cornea.

  • This will allow ablation of a specific protein at different times in infection and allow one to determine if the same "mutation" may have early and late phenotypes.

  • Moreover, RNAi will permit the ablation of essential gene products, at any time point in infection, or on a desired parasitic stage following synchronization.


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