Example sentences for: ablate

How can you use “ablate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 5G-YMHA contains mutations in the reverse transcriptase motif YMDD of P (D513H and D514A) that ablate DNA polymerization [ 17].

  • Post-transcriptional gene silencing using synthetic short interfering RNA (siRNA) molecules has been recently used to ablate specific mRNAs and thus, produce phenotypic mutations in specific genes [ 16 17 ] . We have adopted this technology to knockdown specific gene products in RNA viruses that are obligatory intracellular parasites [ 18 ] . In the present study, we have successfully used a similar strategy to generate phenotypic PP1-deficient P. falciparum parasites.

  • While our manuscript was being written, McRobert and McConkey [ 44 ] achieved similar success in using the RNAi strategy to ablate dihydroorotate dehydrogenase (DHODH) of P. falciparum . Although the protein level was not directly monitored, the loss of DHODH mRNA was confirmed by RT-PCR.

  • However, since the 1B4 mutation did not ablate hnRNP A2/B1 gene expression, it is unlikely to be useful for studies of hnRNPA2/B1 gene function.

  • Indeed, the successful use of RNA interference to ablate PfPP1 confirms its essential role on parasitic growth.


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