Example sentences for: abasic

How can you use “abasic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Of the four protein areas that bind to the DNA 3' of the abasic site, mutating F266 (molego 10) or W280 (middle of molego 11) decreases APE activity [ 33 ] . The F266 mutation is particularly interesting, as the mutants at this position had reduced substrate specificity and enhanced 3'-exonuclease activity.

  • The residues contacting the region 3' to the abasic site come from three different uniquely conserved areas of APEs (molegos 6,7a, 10) as well as 11, a molego that is similar to that in DNase-1.

  • The 3' approach to the DNA [ 34 ] and the wide area covered by the protein on both sides of the abasic site [ 14 ] are both consistent with the need to hold the product until the correct polymerase moves in 5' to 3' to complete the repair [ 25 ] . This implies that the mammalian enzyme has evolved to be processive, to facilitate more efficient functioning of the overall BER pathway, and may not be optimized for simple catalysis.

  • The abasic sugar-phosphate backbone is then cleaved by an apurinic/apyrimidinic endonuclease or lyase.

  • Is the specificity of APE determined by binding 3' to an abasic site?


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